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In vitro studies of test models suggest that by interacting with the GHS receptors, Ipamorelin may act on somatotroph cells in the anterior pituitary gland, which may activate various intracellular signaling pathways

AJMC , Syrop J., Current State of Electronic PA in the US (Oct 2015) ( [81] )

Not only that, but when analyzing responsiveness to GHRH and/or GHRP by double-reverse hemolytic plaque assay, the presence of at least three functionally distinct somatotroph subpopulations were identified (6)

Although the exact physiological role remains under study, DSIP has been associated with modulation of hypothalamic and pituitary activity in experimental models