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While p53 modulators, including FOXO4-DRI, MDM2 inhibitors, and USP7 inhibitors have shown senolytic effects by selectively eliminating senescent cells or promoting their apoptosis in the laboratory, translating these findings to the clinic have so far been unsuccessful

This section delves into strategies aimed at mitigating these risks, ensuring patient safety, and maintaining therapeutic efficacy

(D) Pie chart of potential PUF-8 target genes (800, 3.6%) that contain at least one PBE

Bush MA, Matthews JE, De Boever EH, Dobbins RL, Hodge RJ, Walker SE, Holland MC, Gutierrez M, Stewart MW

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