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Edaravone, a free-radical scavenger approved in Japan for acute ischemic stroke, has demonstrated protective effects in tourniquet- induced muscle I/R in murine models but is not approved for limb I/R indications outside Japan.38 Mitochondrial permeability transition pore inhibitors reduce skeletal muscle and renal injury in rat lower-limb I/R models but are limited in clinical translation due to immunosuppressive and pharmacokinetic constraints.39 Nitric oxide donors and L-arginine improve microvascular perfusion, enhance endothelial function, and reduce oxidative stress
The ability of HGF to promote wound healing because of its angiogenic and mitogenic activities supports the use of HGF mimics to enhance the wound healing process
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