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High blood levels thus achieved have therapeutic value

doi: 10.3382/ps.2011-01591 83 YangL.LiuG.LianK.MooreD

The truncation reduces IGFBP binding similar to the LR3 modification, but DES IGF-1 retains a much shorter circulating half-life (typically reported in the 20 to 30 minute range) because the rest of the molecule remains susceptible to standard proteolytic clearance

Benzoyl Peroxide: This can deactivate the tretinoin molecule, making it less effective