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Mechanistically, SYNCRIP upregulates SIRT1 expression at both the transcriptional and post-transcriptional levels by stabilizing SIRT1 mRNA

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119 Similarly, a randomized controlled trial in 41 tinnitus patients found 50 mg of zinc daily for two months resulted in reduced subjective assessment of tinnitus severity in 82% of those receiving zinc, but there was not a statistically significant reduction in tinnitus loudness