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Shankar B, Zhang J, Naqash AR, et al
The metabolism of glutamate and glutamine in the body is quite complicated because glutamine is produced from glutamate in muscles
Other side effects reported ranged from lipohypertrophy at injection site, papilloedema (related to cranial hypertension), and facial nerve paralysis [276, 285], however symptoms did not prevail after treatment pause and restarting with lower doses [268]
Therefore, precise spatiotemporal regulation of ferroptosis induction is crucial to achieving clinical controllability and therapeutic efficacy
The accumulated lactate leads to low pH in the TME or acidification, which limits the activity of immune cells by suppressing the activation of NK cells and confining the production of IFN-, and induction of apoptosis in T and NK cells [298, 302, 303]
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