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Numerous meta-analyses have evaluated the general risk of serious infections or opportunistic infections, defined as development of a mycobacterial, fungal, or viral infection, during treatment with biologics and/or nbDMARDs

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ME/CFS is a multi-systemic disease affecting somewhere between 0.1% and 2.5% of the population.[ref] In the US, around 1% of the population is diagnosed with ME/CFS.[ref] In some parts of the world, it is commonly referred to as myalgic encephalomyelitis (ME), while in other areas, such as the US, it is sometimes still called chronic fatigue syndrome (CFS)