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Healthcare providers should counsel patients that fertility may improve during treatment, emphasizing the importance of reliable contraception

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Discussion In this study we show that (i) acute and chronic administration of the GLP-1 receptor agonist Ex-4 results in a significant elevation in heart rate, (ii) centrally administered Ex-4 depresses spectral measures of HRV both acutely and chronically, and (iii) Ex-4 inhibits neurotransmission to cardiac vagal neurons in the nucleus ambiguus