293 NQO1, an enzyme involved in the elimination of ROS, is inhibited by HBx, leading to decreased GSH levels and increased susceptibility of hepatoma cells to oxidative damage, cumulating in HBV-associated pathogenesis of chronic liver diseases
Abbreviations BBB: Bloodbrain barrier CFS: Chronic fatigue syndrome CNS: Central nervous system CoA: Coenzyme A COVID-19: Coronavirus disease 2019 CrAT: Carnitine acetyltransferase CRP: C-reactive protein HPA: Hypothalamicpituitaryadrenal IDO: Indoleamine 2,3-dioxygenase IL-2: Interleukin-2 IMD: Immunometabolic depression MDD: Major depressive disorder ME: Myalgic encephalomyelitis mGluR2: Metabotropic glutamate receptor 2 MS: Multiple sclerosis NMDA: N -Methyl-d-aspartate NMR: Nuclear magnetic resonance Nrf2: Nuclear factor erythroid 2-related factor 2 OCTN2: Organic cation novel type 2 transporter OCT1: Organic cation transporter 1 PAIS: Post-acute infection syndromes PASC: Post-acute sequelae of SARS-CoV-2 infection PDC: Pyruvate dehydrogenase complex PGD2S: Prostaglandin D2 synthase gene QUIN: Quinolinic acid ROS: Reactive oxygen species Trp: Tryptophan TCA: Tricarboxylic acid HO-1: Heme oxygenase 1 PUFAs: Polyunsaturated fatty acids CACT: Carnitine-acylcarnitine translocase MRI: Magnetic resonance imaging [ 18 F]FDG-PET/CT: [ 18 F]Fluorodeoxyglucose positron emission tomography/computed tomography References Abraham NG, Kappas A (2008) Pharmacological and clinical aspects of heme oxygenase
To promote optimal health, it is essential to adopt lifestyle choices that support and enhance glutathione levels, which can include consuming a diet rich in sulfur-containing foods, regular exercise, and considering glutathione supplementation when necessary
doi:10.1146/annurev-nutr-120524-043056 Quinn M, Halsey J, Sherliker P, et al
Recent studies have shown that simvastatin has a promising anti-tumor effect in gliomas [19, 20]
