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655 In addition to its role in glycolysis and ATP production, PKM2 also regulates the redirection of glycolytic intermediates to the pentose phosphate pathway, thereby generating NADPH, which is critical for cellular redox homeostasis, 656 thus shielding cancer cells from oxidative stress

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A report of opioid use and/or prescription for chronic opioids should clue the provider into the possibility of a patient experiencing opioid withdrawal

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