glp-1 drugs thyroid cancer Letter: Association Between Incretin Mimetics and Medullary Thyroid cancer survivor wondering about

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Future large long-term RCTs with primary or secondary outcomes, including thyroid disorders and real-world data, are needed to elucidate the association between GLP-1 receptor agonists and the risk of various thyroid disorders, particularly thyroid cancer

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PI3K activates protein kinase B (Akt), which inactivates several important substrate proteins, such as glycogen synthase kinase 3 (GSK-3) 18 and forkhead box O, 19 and activates mammalian target of rapamycin (mTOR)