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Although vitamin B12 deficiencies are rare in the U.S., certain medications and health conditions such as pernicious anemia can affect the absorption of vitamin B12 and contribute to a deficiency

A study by Forsling et al

An open-label study (n=42) found that IV NAC (50 mg/kg) combined with oral NAC (500 mg twice daily) for 3 months increased brain glutathione levels (measured by MRS), increased dopamine transporter binding (measured by DaTscan), and improved UPDRS motor scores (Monti et al., PLoS One, 2016) [53]

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If a spot remains for weeks or changes shape, it is better to get it checked