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Further studies revealed that treatment with N-acetylcysteine (NAC), a GSH precursor, significantly upregulates the GSH/GSSG ratio and increases the expression of GPX4, NRF2, and HO-1, effectively inhibiting ferroptosis (Zhang S

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Muscle Nerve 66, 240252

Together, these findings demonstrate that Humanin acts as a muscle-derived myokine that is upregulated in obesity and secreted in response to lipid overload