Heerspink HJL, Kiyosue A, Wheeler DC, Lin M, Wijkmark E, Carlson G, Mercier AK, strand M, Ueckert S, Greasley PJ, Ambery P
IFN- 1b plus atorvastatin has been shown in some studies to significantly lower high-sensitivity C-reactive protein levels in patients, indicating an anti-inflammatory effect of atorvastatin in MS (281)
In addition, RSL3, another ferroptosis inducer, can covalently bind to selenocysteine at the active site of GPX4, thus directly inhibiting the phospholipid peroxidase activity of GPX4 [54]
Advise observing for negative responses and modifying methods accordingly
To compare cellular versus whole-organismal metabolism, we tested glucose uptake and mitochondrial function, using 2-NBDG glucose uptake and MitoTracker Green multiplexed with MitoTracker Red CMXRos, as surrogate analyses for T cell metabolic fitness across conditions (Fig