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The SELECT cardiovascular trial [2] confirmed these microbiome changes persist long-term, with sustained alterations in bile acid metabolism affecting gut bacterial composition even after 2 years of treatment at the 2 Easing constipation: Constipation is one of the most common semaglutide side effects

A monitoring visit is scheduled at 4 weeks

Reported tolerability in the available human observational work is high: no consistent pattern of adverse effects has been published, although the absence of placebo-controlled trials means subtle effects cannot be excluded