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And there is a big, bigger belief, at least over there, that disease begins in the mouth a lot of times over here in functional medicine here, the disease begins in the gut

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As an example, immunopathologic vasculopathy in a hypoxic model of pulmonary hypertension was found to be driven by G6PD-induced pro-inflammatory epigenetic signaling including upregulated expression of pro-inflammatory factors (e.g., tumor necrosis factor-alpha [TNF-]), increased numbers of activated macrophages, and activated platelets and conversely, was able to be mitigated with G6PD deficiency ( G6PD-dependent ROS generation is also important in innate immune sensing by macrophages ( Figure 1B-1 )

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Front Aging Neurosci 8:308