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[11] The researchers concluded that Ipamorelin accelerates gastric emptying in a rodent model of postoperative ileus through the stimulation of gastric contractility by activating a ghrelin receptor-mediated mechanism involving cholinergic excitatory neurons. Some of the research observations in this and other studies suggest that residual radiolabeled food remaining in the stomach of rats with POI was less after the influence of Ipamorelin, even when compared to rats without POI

MOTS-c vs Tesamorelin: Tesamorelin stimulates growth hormone release, which drives visceral fat reduction through a different pathway: increased GH increased IGF-1 direct lipolysis in visceral adipose tissue

Conversely, starting at excessive doses (500+ mcg) causes unnecessary side effects prompting premature discontinuation before benefits appear