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Mitochondrial dysfunction model: The role of cellular metabolism in differentiation was studied using a mouse model with mitochondrial dysfunction ( mice), where ClpP, a mitochondrial matrix peptidase, is knocked out in intestinal epithelial cells

Researchers may choose this formula when they want to investigate the combined activity of all three peptides within the same study

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In chronic metabolic states like obesity and T2DM, the GLP-1R signaling axis undergoes significant alterations that drive incretin resistance and impaired glucose control (Tzeravini et al., 2026)

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