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Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis

Upon exposure of these macrophages to LPS, the enhancement of intracellular supersulfides via treatment with NAC-S2 almost completely suppressed IL-1 production, which suggests that supersulfides establish a negative feedback loop regulating NLRP3 inflammasome-mediated IL-1 production (110)

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10.1007/s43032-022-00930-1 56 HuangB.LuJ.DingC.ZouQ.WangW.LiH

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