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When You Might Need Higher B12 Doses While the standard RNI of 1.5 mcg per day suffices for most healthy adults, certain medical conditions, dietary patterns, and medications can substantially increase B12 requirements or impair absorption, necessitating higher therapeutic doses under medical supervision

These medications may benefit patients with metabolic liver disease regardless of diabetes status, especially if metabolic risk factors are present

Sources How to use Mounjaro, Lilly [accessed 11 February 2025] Mounjaro KwikPen 10mg solution for injection in pre-filled pen, emc [accessed 11 February 2025] Obesity, NHS [accessed 11 February 2025] User manual: Mounjaro KwikPen 10mg solution for injection in pre-filled pen, emc [accessed 11 February 2025]

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