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GLP-1RAs exert key physiological effects by activating the GLP-1 receptor

LgBiT and an OMBP-MBP tag were added to the C-terminus of the receptor with a TEV site between them

A recent review on bio-availability enhancement of poorly water-soluble drugs by using bioenhancer and nanoparticulate drug delivery system

Although the absolute difference in cancer incidence with GLP-1 receptor agonists compared with dipeptidyl peptidase-4 (DPP-4) inhibitors is small, the relative risk difference observed in the study could have an impact on a population level, lead author Lucas A

A dysfunctional OCTN2 transporter reduces this gradient because of a compromised myocardial carnitine transport as well as a result of low plasma carnitine concentration subsequent to excessive renal loss of carnitine