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Moiseev, S
Because the milligram amount is fixed, a lighter body gets more drug exposure per pound: roughly 22% more at 70 kg and about a third less at 120 kg, compared with a 90 kg reference. The dose still comes from response and tolerability, but a lighter person is running a hotter exposure at the same number on the vial
Once-Weekly Semaglutide in Adults with Overweight or Obesity. NEJM
It forces your skin to shed dead cells and generate new ones at a faster rate
If you're trying to preserve muscle while losing fat (which you absolutely should be, per the protein research above), higher protein is non-negotiable
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