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EcN can up-regulate the expression and membrane localization of tight junction proteins in intestinal epithelial cells, contribute to repair the damaged mechanical barrier of the intestinal epithelium, and reduce the translocation of intestinal bacteria, lipopolysaccharides, and other hepatotoxic substances to the liver [57]

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The key to effective B12 therapy lies in tailoring the dosage to the individual patients condition and response, notes a leading expert in the field of nutritional neuropathy treatment