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Such genetic predispositions could indeed limit the effectiveness of GLP-1 RAs like tirzepatide and semaglutide in patients whose OSA is primarily driven by these underlying physiological mechanisms rather than solely by excess adiposity

For the GPX4 siRNA experiment presented in Fig

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Pathological astrocytic morphotypes are (i) thorn-shaped astrocytes with tau inclusions in soma and proximal processes, and in the subpial and perivascular endfeet and (ii) granular-fuzzy astrocytes with fine granular tau inclusions mainly in the perinuclear region