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At the same time, genome-wide loss of DNA methylation is observed in tumor cells compared to healthy cells inducing chromosomal instability, loss of imprinting as well as the previously described oncogene activation

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In 2005, patients with tropical pancreatitis were treated orally with curcumin (500 mg) and piperine (5 mg) for 6 weeks and found a reduction in erythrocyte Malondialdehyde (MDA) levels and an increase in Glutathione compared with placebo [78]

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