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The OASIS 4 clinical trial published in the New England Journal of Medicine in 2025 followed adults with overweight or obesity for 71 weeks

J Clin Med 9(2):336 Kaysen GA, Johansen KL, Chertow GM et al (2015) Associations of Trimethylamine N-Oxide with nutritional and inflammatory biomarkers and cardiovascular outcomes in patients new to dialysis

Methionine is an amino acid that acts as a lipotropic agent to prevent excess fat buildup in the liver and the body