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Key ones include pregnancy, uncontrolled hypertension, glaucoma (phentermine), seizure disorders (bupropion component of Contrave), and significant cardiovascular disease history

Mounjaro (Tirzepatide) evolved this by adding GIP, creating a dual-agonist that improves insulin sensitivity

It is also used in comparative receptor binding studies examining IGF-1R versus insulin receptor (IR) cross-reactivity and downstream signal divergence

Formulations created by specialty pharmacies that customize drugs to meet the needs of specific patients are referred to as compounded semaglutide