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Methods: This meta-analysis was registered prospectively in PROSPERO (CRD 420251147337)

Neurogenic inflammation (inflammation that affects the peripheral nervous system, a network of nerves that runs throughout the head, neck, and body) and neuroinflammation (inflammation that affects the brain and spinal cord) are involved in migraines with and without auras and chronic migraines, according to a study published in the journal FASEB BioAdvances

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The STEP1 and SURMOUNT trials demonstrated sustained clinically relevant reduction in body weight with semaglutide and tripeptide, respectively, in patients with overweight and obesity

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