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Some immune system-altering medications used by children with ASD include: intravenous immunoglobulins (IVIG), anti-viral medications, anti-fungal medications, and steroids

As LTB4 is synthesized by 5-lipoxygenase, attempts have been made to inhibit this enzyme (e.g., GSK2190915, Zileuton) but have also failed because of side effects including hepatic toxicity [110]

More importantly, maternal infections affecting the immune axis increase offspring risk, and molecular links have been vigorously studied in animal models of maternal immune activation that recapitulate neurodevelopmental defects 4,5

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