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Subsequent large analyses did not confirm a significant increase in pancreatitis incidence due to GLP-1 RAs ( [64] ) ( [107] ), although a small elevation in risk cant be entirely ruled out (this is discussed under Safety)
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Diabet Med 1990;7:1624
If tirzepatide causes you to become dehydrated, and you are already on bupropion which has lowered your seizure threshold, the combined situation could increase seizure risk beyond what either medication would cause independently
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