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stimulates pulsatile GH release without raising cortisol or prolactin Key safety concern / Unknown effects on a still-maturing hypothalamic-pituitary-gonadal axis Guideline position / No endorsement from Endocrine Society, AAP, or AACE for pediatric use Compounding status / Available only through 503A/503B compounders
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Drugging this type of GPCR with small molecules has its challenges say Jeff Finer, chief executive of Septerna, a biotech based in south San Francisco, US
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