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As a glucagon-like peptide-1 (GLP-1) receptor agonist, Trulicity does not create physical dependence, and abrupt discontinuation will not trigger acute medical complications

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Hypoxia-Inducible Factor (HIF) Pathway Hypoxia leads to the stabilization of HIF-1 among hypoxia-inducible factors which then activates genes that help cells adapt metabolically by upregulating glutamine transporter proteins

[DOI] [PubMed] [Google Scholar] 112.Bakos H

Patients treated with Qsymia should be advised to monitor for decreased sweating and increased body temperature during physical activity, especially in hot weather