-Among patients with type 2 diabetes, semaglutide use was associated with significantly lower odds of NAION (OR 0.36, 95% CI 0.250.51) compared with nonGLP-1 therapies
While side effects are common with this class of medications, most are mild-to-moderate and transient
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the longest-lasting common side effect Fatigue and headache: 13 weeks After stopping, it is fully cleared from your system in approximately 5 weeks The key to shorter, milder side effects is following the recommended slow dose titration schedule, eating smaller meals, staying hydrated, and maintaining open communication with your prescribing provider about any symptoms that feel unmanageable
The clinical success of tirzepatide has revamped the attention toward GLP-1R/GCGR dual agonists and tri-agonists GLP-1R/GCGR/GIPR in which the identification of an ideal receptor balance is required to maximize efficacy and mitigate safety concerns
