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trimethylamine solution 60g was added in 250ml three-necked flask, strried and cooled to 10-20C, after S-epichlorohydrin (35g) being dripped in, the mixture was strried and kept at 10 20C for 2-4 hours, and then the reacting temperature was raised to and kept at 30 70C for 2 to 4 hours, evaporated to appropriate amount under a reduced pressure, crystallized by freezing, then dried to give L-3-chloro-2-hydroxypropyl trimethyl ammonium (55.2g), yield 89.0%, m.p

However, the most potent are the aromatic amino acids, l-phenylalanine and l-tryptophan (137)

doi: 10.1016/j.molmet.2021.101352

Nat Med (2017) 23:5017