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Regulation of myelin structure and conduction velocity by perinodal astrocytes
R., Kulyk, S., Lawson, J
Adverse effects observed in trials to date include: Gastrointestinal symptoms nausea, vomiting, diarrhoea, and constipation (common with GLP-1 receptor agonists) Reduced appetite and weight loss , which may be excessive in some individuals Elevated heart rate , a concern noted with glucagon receptor agonism As with other incretin-based therapies, there is also a class-level signal for acute pancreatitis and gallbladder disease (including cholelithiasis and cholecystitis)
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Of particular significance is the remethylation of homocysteine ( Hcy ) to methionine, which not only detoxifies Hcy but also generates S-adenosylmethionine ( SAM )the universal methyl donor required for DNA methylation, neurotransmitter synthesis, membrane phospholipid remodeling, and creatine production
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