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Given the vital role of the gut microbiome in glucose homeostasis, we hypothesize that statin utilization may contribute to the gut microbiome dysbiosis, which potentially affects circulating metabolites and host glucose homeostasis

Exercise induces the release of myokines, such as apelin and irisin, alongside increased levels of BDNF ( GLP-1RAs act on overlapping hypothalamic circuits, reducing appetite and improving energy balance and have been shown to promote browning of white adipose tissue, contributing to increased energy expenditure

When free radicals and antioxidants are out of balance, it creates oxidative stress

Individuals with cardiac history should use Rufinamide with caution, as it can potentially alter heart rhythm