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In white adipose tissue of obese, insulin-resistant and aged mammals, NNMT is dramatically upregulated and because it consumes both the universal methyl donor (SAM) and the NAD precursor (nicotinamide), its hyperactivity simultaneously depletes the cellular methylation reserve and the NAD-salvage pool [1,2]

From the preclinical data for putative benefits there were also important side effects noted

65 Oleuropein and its derivative hydroxytyrosol are polyphenols found in olives, EVOO, and olive leaf