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Use of sodium-glucose co-transporter 2 (SGLT-2) inhibitors is currently classified as off-label in individuals less than 18 years of age in Canada

Based on the studies with isolated perfused rat liver, Masuda [59] suggested that covalent binding of carbon tetrachloride metabolites rather than lipid peroxidation has a significant role in the production of centrilobular necrosis following carbon tetrachloride administration

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