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These trials include oral semaglutide up to 14mg once daily as initial therapy of diabetes, in various combinations with oral or injected glucose-lowering agents, and compared to other medications (sitagliptin, empagliflozin and liraglutide) or placebo, and stratified to include populations with additional risk such as patients with chronic kidney disease and those at high risk for cardiovascular disease

This cold-chain requirement preserves the peptide structure and biological activity essential for appetite suppression and metabolic effects

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