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While the magnitude was generally modest (single-digit beats per minute in most cases), this cardiac signal is one of the primary reasons retatrutide remains investigational and is undergoing extensive Phase 3 safety monitoring

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Other organs are often involved in the deposition of amyloid (e.g., kidney, nasal submucosa, lamina propria intestines, heart, salivary gland, thyroid, adrenal cortex, lung, tongue, testis, ovary, and aorta)