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Your provider can order labs to check thyroid function, metabolic markers, and nutritional status

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However, Er-targeted therapies are likely to worsen outcomes in carriers of the highly common PNPLA3 p.I148M variant, where ER activation may increase the number of pathogenic malfunctioning defective PNPLA3 enzymes on lipid droplets to drive liver lipid accumulation and worsen MASLD severity (47)

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