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The results indicated that RGD-modified NPs are the safe and promising therapeutic strategy for delivering non-viral gene vectors to the brain for ischemic stroke therapy ( Toxicity Status of Nanoparticles There is a lack of research and a lack of complete understanding of the mechanisms of NPs mediating toxicity on exposures to humans

Exp Neurol 2015;272:109-19.ArticlePubMedPMC 64

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Seven year itch: Pan-assay interference compounds (PAINS) in 2017-Utility and limitations