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Additionally, ROS promotes pro-inflammatory signaling (e.g., NF-B activation) and endothelial adhesion molecule expression (e.g., VCAM-1, ICAM-1, TNF-), further exacerbating vascular stiffness and atherosclerosis (Zeng and Yang, 2024)

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In the one available PET study in LLD, five older adults showed elevated TSPO in the sub-genual cingulate gyrus, along with hippocampal subfield atrophy and increased CRP levels, compared to controls [281]