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The difference is that MOTS-c gets there through metabolic signaling and gene expression while NAD+ gets there through substrate supply and repair enzyme activation

Most of these agents work by inhibiting the production of the tyrosinase enzyme, which is essential for producing melanin

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10.1016/S0891-5849(01)00480-4 [DOI] [PubMed] [Google Scholar] 30.Jones DP

Furthermore, a dipyrrole is formed from the photodegradation of bilirubin ( 234 ), as discussed in the following section