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The primary concerns are cardiovascular strain (increased heart rate/blood pressure) and severe dehydration/malnutrition due to the combined effect of both drugs on your central nervous system and gut.

In either case, while NAC may promote athletic performance in the short-term, like other antioxidant supplements, it might harm performance in the long-term by decreasing the body's ability to adapt to the stress induced by exercise

Additional information about the NIH Roadmap can be found at www.nihroadmap.nih.gov

Side effects without clear benefits, reduce dose or switch formulations

So they're not having to pull up their bootstraps when they're just exhausted