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Updated March 2026.

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Its expression is significantly increased in lung adenocarcinoma, downregulated in gastric and colorectal cancers and altered during the differentiation of pluripotent embryonic stem cells (Liu et al., 2017

It is used mainly as add-on to metformin when metformin alone is insufficient for glycemic control, particularly when there is a desire to minimize the risk for hypoglycemia

It can help individuals come to terms with their uncomfortable thoughts and feelings rather than trying to waive them off or control them