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Figure 1 The adrenal medulla, an extension of the sympathetic nervous system, on the other hand, produces catecholamines such as epinephrine (adrenaline) and norepinephrine ( Figure 1 ), which have widespread impacts on the cardiovascular system, metabolism, and other body systems

Understanding these potential mechanisms helps clinicians and patients identify strategies to minimise discomfort whilst maintaining adequate B12 intake

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Hence, the findings that tamoxifen resistance is associated with increased enolase I expression is consistent with the premise that tamoxifen selectively targets P-gp-expressing tumor cells which have higher ATP needs to fuel P-gp