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Mechanism of reactive oxygen species-guided immune responses in gouty arthritis and potential therapeutic targets

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Jin L, Jin F, Guo S et al (2022) Metformin inhibits NLR family pyrin domain containing 3 (NLRP)-relevant neuroinflammation via an adenosine-5-monophosphate-activated protein kinase (AMPK)-dependent pathway to alleviate early brain injury after subarachnoid hemorrhage in mice

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A recent small study of healthy older adults given glyNAC, a supplement that increases glutathione levels, showed lower oxidative stress and inflammation after 24 weeks of treatment (10)