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Melittin was used for treating breast cancer brain metastases (BCBM), by conjugating AMD3100, a small molecule antagonist of CXCR4 highly expressed in BCBM, with poly(lactone-co--amino ester) nanoparticles and melittin delivered via AMD3100 nanoparticles effectively inhibited tumor growth in mice of BCBM model (Zhou et al., 2020)

Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion

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They also suffer from problems with their serotonin levels