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Side effects are rare and typically limited to mild local irritation at the injection site

b , Illustration of sampling and workflow for scRNA-seq of DRG cells from control and autoantibody injected mice

A study measuring only serum KLOW concentration would conclude the compound is "gone" by 48 hours, but tissue samples taken at 7296 hours post-administration still show elevated phosphorylated AMPK levels, indicating ongoing metabolic effects

Mean weight reductions were greater with all cagrilintide doses (roughly 6.0% to 10.8%) than with placebo (3.0%), and the top 4.5 mg dose modestly out-performed the active comparator, once-daily liraglutide 3.0 mg (10.8% vs 9.0%)

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